Advancing Characterization Strategies for mRNA-based Therapies

Time: 9:30 am
day: Day Two


  • Quantify plasmid topological forms to ensure starting material quality
  • Determine mRNA purity and sequence length with a reliable size estimation
  • Elucidate RNA structural modeling by chemical probing and sequencing
  • Reliably identify the different mRNA capping structures as well as distinguish between uncapped and capped structures.
  • Determine drug efficacy and safety by identifying oxidative impurities in lipid nano particle formulations