Measuring Replication Competence, Integrity & dsRNA in saRNA to Strengthen Potency, Reduce Immunogenicity & Build Regulatory Confidence
- Characterizing saRNA replication intermediates and byproducts to understand their impact on potency and safety
- Developing sensitive assays to monitor integrity and control dsRNA levels to reduce unwanted immunogenicity
- Translating early saRNA assays into QC-ready methods to build regulator confidence in this emerging modality