Innovations in Addressing dsRNA Challenges for Advancing mRNA Therapeutics

Time: 3:01 pm
day: Pre-Conference Day


One of the main challenges for mRNA therapeutics is the presence of doublestranded RNA (dsRNA), which can trigger unwanted immune responses and limit the efficacy of mRNA therapies. A key development in tackling dsRNA challenges is the refinement of mRNA design and modification techniques. Scientists have been working to engineer mRNA molecules that have reduced dsRNA content, thereby minimizing the potential for immune activation. Overcoming these hurdles will pave the way for more precise, potent, and safer mRNA therapies with the potential to revolutionize the treatment of various diseases.

Join this session to discuss:

• dsRNA ability to effectively target specific mRNA sequences, resulting in increased specificity and accuracy in mRNA analysis

• The possible strategies to improve its specificity and reduce the potential for offtarget effects

• The regulatory hurdles in the use of dsRNA in mRNA analytical development to ensure safety and efficacy of these technologies